{"id":21308,"date":"2026-05-07T14:13:21","date_gmt":"2026-05-07T06:13:21","guid":{"rendered":"https:\/\/ma.xqsz.net\/?p=21308"},"modified":"2026-05-07T14:13:21","modified_gmt":"2026-05-07T06:13:21","slug":"hr%e9%98%b3%e6%80%a7-her2%e9%98%b4%e6%80%a7%e6%99%9a%e6%9c%9f%e4%b9%b3%e8%85%ba%e7%99%8c%e6%b2%bb%e7%96%97%e7%8e%b0%e7%8a%b6%ef%bc%9a%e4%bb%8e%e4%b8%80%e7%ba%bf%e8%a7%84%e8%8c%83%e5%88%b0%e4%ba%8c","status":"publish","type":"post","link":"https:\/\/ma.xqsz.net\/index.php\/2026\/05\/07\/21308\/","title":{"rendered":"HR\u9633\u6027\/HER2\u9634\u6027\u665a\u671f\u4e73\u817a\u764c\u6cbb\u7597\u73b0\u72b6\uff1a\u4ece\u4e00\u7ebf\u89c4\u8303\u5230\u4e8c\u7ebf\u63a2\u7d22\u7684\u8fdb\u5c55"},"content":{"rendered":"<p class=\"ds-markdown-paragraph\">HR\u9633\u6027\/HER2\u9634\u6027\u662f\u4e73\u817a\u764c\u6700\u5e38\u89c1\u7684\u5206\u5b50\u4e9a\u578b\uff0c\u7ea6\u5360\u5168\u90e8\u4e73\u817a\u764c\u768460%\uff5e70%\u3002\u5bf9\u4e8e\u665a\u671f\u9636\u6bb5\u7684\u60a3\u8005\uff0c\u5982\u4f55\u4f18\u5316\u6cbb\u7597\u7b56\u7565\u3001\u5ef6\u957f\u751f\u5b58\u671f\u5e76\u63d0\u9ad8\u751f\u6d3b\u8d28\u91cf\uff0c\u59cb\u7ec8\u662f\u4e34\u5e8a\u5173\u6ce8\u7684\u7126\u70b9\u3002\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u9776\u5411\u6cbb\u7597\u548c\u7cbe\u51c6\u533b\u5b66\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u8be5\u4e9a\u578b\u7684\u6cbb\u7597\u683c\u5c40\u53d1\u751f\u4e86\u8f83\u4e3a\u6df1\u523b\u7684\u53d8\u5316\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/objectmc2026.oss-cn-shenzhen.aliyuncs.com\/yhdoc\/202605\/07\/202605071104291484000920.png\" \/><\/p>\n<p class=\"ds-markdown-paragraph\"><strong>\u4e00 \u7ebf\u6cbb\u7597\uff1aCDK4\/6\u6291\u5236\u5242\u7684\u57fa\u77f3\u5730\u4f4d<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u76ee\u524d\uff0c\u5bf9\u4e8eHR\u9633\u6027\/HER2\u9634\u6027\u665a\u671f\u4e73\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u56fd\u5185\u5916\u6307\u5357\u5747\u80af\u5b9a\u4e86CDK4\/6\u6291\u5236\u5242\u5728\u8be5\u9886\u57df\u7684\u91cd\u8981\u4ef7\u503c\u3002\u8fc7\u53bb\u6570\u5e74\u95f4\uff0c\u9488\u5bf9CDK4\/6\u6291\u5236\u5242\u7684\u5faa\u8bc1\u8bc1\u636e\u4e0d\u65ad\u5f97\u5230\u592f\u5b9e\uff0c\u591a\u9879\u5927\u578b\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08\u5982PALOMA\u3001MONALEESA\u3001MONARCH\u7cfb\u5217\u7814\u7a76\uff09\u4e00\u81f4\u8bc1\u5b9e\uff0cCDK4\/6\u6291\u5236\u5242\u8054\u5408\u5185\u5206\u6ccc\u6cbb\u7597\u76f8\u8f83\u4e8e\u5355\u7eaf\u5185\u5206\u6ccc\u6cbb\u7597\uff0c\u80fd\u591f\u663e\u8457\u5ef6\u957f\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff0c\u90e8\u5206\u836f\u7269\u8fd8\u53ef\u4ee5\u6539\u5584\u603b\u751f\u5b58\u3002\u56e0\u6b64\uff0c\u65e0\u8bba\u5728\u56fd\u5185\u8fd8\u662f\u56fd\u9645\u6307\u5357\u4e2d\uff0cCDK4\/6\u6291\u5236\u5242\u8054\u5408\u5185\u5206\u6ccc\u6cbb\u7597\u5df2\u6210\u4e3a\u4e00\u7ebf\u6cbb\u7597\u7684\u7b56\u7565\u4e4b\u4e00\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u4e0e\u6b64\u540c\u65f6\uff0c\u968f\u7740\u5206\u5b50\u7cbe\u51c6\u9776\u5411\u68c0\u6d4b\u6280\u672f\u7684\u6301\u7eed\u8fdb\u6b65\uff0c\u5bf9\u4e8eHR\u9633\u6027\/HER2\u9634\u6027\u60a3\u8005\uff0cPAM\u901a\u8def\u68c0\u6d4b\u53caPARP\u901a\u8def\u7684\u68c0\u6d4b\u4e5f\u9010\u6e10\u88ab\u7eb3\u5165\u6307\u5357\u7684\u8ba8\u8bba\u8303\u7574\u3002\u4f46CDK4\/6\u6291\u5236\u5242\u5728\u4e00\u7ebf\u6cbb\u7597\u4e2d\u7684\u91cd\u8981\u6027\uff0c\u76ee\u524d\u79ef\u7d2f\u4e86\u8f83\u4e3a\u4e30\u5bcc\u7684\u5faa\u8bc1\u8bc1\u636e\u3002\u603b\u4f53\u800c\u8a00\uff0cHR\u9633\u6027\/HER2\u9634\u6027\u665a\u671f\u4e73\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u7b56\u7565\u76f8\u5bf9\u89c4\u8303\u4e14\u660e\u786e\u3002<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>\u4e8c \u7ebf\u6cbb\u7597\uff1a\u591a\u5143\u9009\u62e9\u4e0b\u7684\u4e2a\u4f53\u5316\u7b56\u7565<\/strong><\/p>\n<p><img decoding=\"async\" src=\"http:\/\/objectmc2026.oss-cn-shenzhen.aliyuncs.com\/yhdoc\/202605\/07\/202605071104441843241900.png\" \/><\/p>\n<p class=\"ds-markdown-paragraph\">\u76f8\u8f83\u4e8e\u4e00\u7ebf\u6cbb\u7597\u7684\u89c4\u8303\u6027\uff0cHR\u9633\u6027\/HER2\u9634\u6027\u665a\u671f\u4e73\u817a\u764c\u7684\u4e8c\u7ebf\u6cbb\u7597\u76ee\u524d\u8fd8\u6ca1\u6709\u5b8c\u5168\u7edf\u4e00\u7684\u65e2\u5b9a\u6807\u51c6\u3002\u8fd9\u79cd\u201c\u5c1a\u672a\u5b9a\u8bba\u201d\u7684\u72b6\u6001\u5e76\u975e\u610f\u5473\u7740\u6cbb\u7597\u624b\u6bb5\u532e\u4e4f\uff0c\u6070\u6070\u76f8\u53cd\uff0c\u5b83\u53cd\u6620\u4e86\u968f\u7740\u7cbe\u51c6\u68c0\u6d4b\u6280\u672f\u7684\u666e\u53ca\uff0c\u4e34\u5e8a\u533b\u751f\u80fd\u591f\u6839\u636e\u60a3\u8005\u7684\u591a\u91cd\u9776\u70b9\u68c0\u6d4b\u7ed3\u679c\uff0c\u5236\u5b9a\u4e2a\u4f53\u5316\u7684\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u5728\u4e8c\u7ebf\u6cbb\u7597\u4e2d\uff0c\u53ef\u8003\u8651\u7684\u9009\u9879\u5305\u62ec\uff1a\u9488\u5bf9BRCA\u57fa\u56e0\u7a81\u53d8\u7684\u60a3\u8005\uff0cPARP\u6291\u5236\u5242\uff08\u5982\u5965\u62c9\u5e15\u5229\u3001\u5c3c\u62c9\u5e15\u5229\u7b49\uff09\u5177\u6709\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\uff1b\u6b64\u5916\uff0c\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\u7684\u5e94\u7528\u4e5f\u4e3a\u60a3\u8005\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u6cbb\u7597\u9009\u62e9\u3002\u503c\u5f97\u7279\u522b\u63d0\u53ca\u7684\u662f\uff0c\u9664\u7ecf\u5178\u7684CDK4\/6\u6291\u5236\u5242\u5916\uff0c\u56fd\u5185\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578bCDK2\/4\/6\u6291\u5236\u5242\u5421\u6d1b\u897f\u5229\uff0c\u5728\u65e2\u5f80\u5185\u5206\u6ccc\u6cbb\u7597\u8fdb\u5c55\u540e\u7684\u60a3\u8005\u4e2d\u5c55\u73b0\u4e86\u4e34\u5e8a\u6f5c\u529b\u3002\u76ee\u524d\u5df2\u6709\u4e34\u5e8a\u7814\u7a76\u663e\u793a\u8be5\u8054\u5408\u65b9\u6848\u4e3a\u60a3\u8005\u5e26\u6765\u4e86\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u83b7\u76ca\u3002<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>\u6cbb\u7597\u683c\u5c40\u7684\u6574\u4f53\u6f14\u53d8\u4e0e\u5c55\u671b<\/strong><\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"http:\/\/objectmc2026.oss-cn-shenzhen.aliyuncs.com\/yhdoc\/202605\/07\/202605071104572045019381.png\" \/><\/p>\n<p class=\"ds-markdown-paragraph\">\u56de\u987e\u8fc7\u53bb\u4e8c\u4e09\u5341\u5e74\u7684\u53d1\u5c55\u5386\u7a0b\uff0cHR\u9633\u6027\/HER2\u9634\u6027\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u7684\u6cbb\u7597\u5883\u9047\u5df2\u53d1\u751f\u8f83\u5927\u8f6c\u53d8\u3002\u53ef\u9009\u836f\u7269\u4ece\u5355\u7eaf\u7684\u5185\u5206\u6ccc\u6cbb\u7597\u548c\u5316\u7597\uff0c\u6269\u5c55\u5230\u591a\u79cd\u9776\u5411\u836f\u7269\u53ca\u65b0\u578b\u5c0f\u5206\u5b50\u836f\u7269\u3002\u836f\u7269\u53ef\u53ca\u6027\u7684\u663e\u8457\u63d0\u9ad8\uff0c\u76f4\u63a5\u63a8\u52a8\u4e86\u4e34\u5e8a\u6cbb\u7597\u6548\u679c\u7684\u6301\u7eed\u6539\u5584\u3002\u8fd9\u4e9b\u8fdb\u6b65\u4e0d\u4ec5\u4f53\u73b0\u5728\u5927\u578b\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\u66f4\u65b0\u4e2d\uff0c\u4e5f\u53cd\u6620\u5728\u65e5\u5e38\u4e34\u5e8a\u5b9e\u8df5\u7684\u7ecf\u9a8c\u79ef\u7d2f\u548c\u771f\u5b9e\u4e16\u754c\u6570\u636e\u7684\u6536\u96c6\u4e2d\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u672a\u6765\uff0c\u968f\u7740\u66f4\u591a\u65b0\u578b\u9776\u5411\u836f\u7269\u7684\u7814\u53d1\u548c\u751f\u7269\u6807\u5fd7\u7269\u6307\u5bfc\u4e0b\u7684\u5206\u5c42\u6cbb\u7597\u7b56\u7565\u7684\u5b8c\u5584\uff0cHR\u9633\u6027\/HER2\u9634\u6027\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u7684\u9884\u540e\u6709\u671b\u5f97\u5230\u8fdb\u4e00\u6b65\u63d0\u5347\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u7efc\u4e0a\u6240\u8ff0\uff0cHR\u9633\u6027\/HER2\u9634\u6027\u665a\u671f\u4e73\u817a\u764c\u7684\u6cbb\u7597\u5df2\u8fdb\u5165\u7cbe\u51c6\u5316\u3001\u591a\u5143\u5316\u7684\u65f6\u4ee3\u3002\u4e00\u7ebf\u6cbb\u7597\u4ee5CDK4\/6\u6291\u5236\u5242\u8054\u5408\u5185\u5206\u6ccc\u6cbb\u7597\u4e3a\u6838\u5fc3\uff0c\u7b56\u7565\u8f83\u4e3a\u89c4\u8303\uff1b\u4e8c\u7ebf\u6cbb\u7597\u5219\u57fa\u4e8e\u9776\u70b9\u68c0\u6d4b\u7ed3\u679c\uff0c\u53ef\u5728PARP\u6291\u5236\u5242\u3001ADC\u836f\u7269\u53ca\u65b0\u578bCDK2\/4\/6\u6291\u5236\u5242\u7b49\u591a\u79cd\u9009\u62e9\u4e2d\u8fdb\u884c\u4e2a\u4f53\u5316\u51b3\u7b56\u3002\u6cbb\u7597\u836f\u7269\u7684\u4e30\u5bcc\u548c\u7597\u6548\u7684\u63d0\u5347\uff0c\u5145\u5206\u4f53\u73b0\u4e86\u4e34\u5e8a\u7814\u7a76\u4e0e\u5b9e\u8df5\u63a2\u7d22\u7684\u6301\u7eed\u8fdb\u6b65\u3002<\/p>\n<p><strong>\u4e13\u5bb6\u7b80\u4ecb<\/strong><\/p>\n<p id=\"_img_parent_tmp\"><img decoding=\"async\" class=\"aligncenter\" title=\"1778123114421821.png\" src=\"http:\/\/objectmc2026.oss-cn-shenzhen.aliyuncs.com\/yhdoc\/202605\/07\/20260507110514909876353.png\" alt=\"1778123114421821.png\" width=\"650\" height=\"974\" border=\"0\" vspace=\"0\" \/><\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" title=\"1778123132134417.png\" src=\"http:\/\/objectmc2026.oss-cn-shenzhen.aliyuncs.com\/yhdoc\/202605\/07\/20260507110532902283350.png\" alt=\"1778123132134417.png\" width=\"575\" height=\"578\" border=\"0\" vspace=\"0\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>HR\u9633\u6027\/HER2\u9634\u6027\u662f\u4e73\u817a\u764c\u6700\u5e38\u89c1\u7684\u5206\u5b50\u4e9a\u578b\uff0c\u7ea6\u5360\u5168\u90e8\u4e73\u817a\u764c\u768460%\uff5e70%\u3002\u5bf9\u4e8e\u665a\u671f\u9636\u6bb5\u7684\u60a3\u8005\uff0c\u5982\u4f55\u4f18\u5316\u6cbb&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-21308","post","type-post","status-publish","format-standard","hentry","category-1"],"_links":{"self":[{"href":"https:\/\/ma.xqsz.net\/index.php\/wp-json\/wp\/v2\/posts\/21308","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ma.xqsz.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ma.xqsz.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ma.xqsz.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ma.xqsz.net\/index.php\/wp-json\/wp\/v2\/comments?post=21308"}],"version-history":[{"count":1,"href":"https:\/\/ma.xqsz.net\/index.php\/wp-json\/wp\/v2\/posts\/21308\/revisions"}],"predecessor-version":[{"id":21309,"href":"https:\/\/ma.xqsz.net\/index.php\/wp-json\/wp\/v2\/posts\/21308\/revisions\/21309"}],"wp:attachment":[{"href":"https:\/\/ma.xqsz.net\/index.php\/wp-json\/wp\/v2\/media?parent=21308"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ma.xqsz.net\/index.php\/wp-json\/wp\/v2\/categories?post=21308"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ma.xqsz.net\/index.php\/wp-json\/wp\/v2\/tags?post=21308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}